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PUBLICATIONS

One-Pot Chemoenzymatic Cascade for the Enantioselective C(1)-Allylation of Tetrahydroisoquinolines

Jack J. Sangster, Rebecca E. Ruscoe, ​Sebastian C. Cosgrove, Juan Mangas-Sánchez and Nicholas J. Turner* J. Am. Chem. Soc. 2023145, 4431–4437

Stereoselective Three-Step One-Pot Cascade Combining Amino- and Biocatalysis to Access Chiral γ-Nitro Alcohols

Christian Ascaso-Alegre, Raquel P. Herrera, and Juan Mangas-Sánchez* Angew. Chem. Int. Ed. 2022, e202209159

Construction of Chemoenzymatic Linear Cascades for the Synthesis of Chiral Compounds

Christian Ascaso-Alegre and Juan Mangas-Sanchez* Eur. J. Org. Chem. 2022, e202200. Part of the “NextGenOrgChem” Special Collection. (Very Important Paper)

New Trends and Future Opportunities in the Enzymatic Formation of C−C, C−N, and C−O bonds

Sangster JJ, Marshall JR, Turner NJ, and Mangas-Sanchez* J. ChemBioChem 2022, 23, e2021004

Expanding the synthetic scope of biocatalysis by enzyme discovery and protein engineering.

Marshall JR, Mangas-Sanchez J*, and Turner NJ*. Tetrahedron 2021, 82, 131926.

Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination.

Marshall JR, Peiyuan Y, Montgomery SL, Finnigan JD, Thorpe TW, Palmer RB, Mangas-Sanchez J, et al. Nature Chem. 2021, 13, 140-148

Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases.

Mangas-Sanchez J, Sharma M, Cosgrove SC, Ramsden JI, Marshall JR, Thorpe TW, et al. Chem Sci 2020, 11, 2251-2262.

Engineered Formate Dehydrogenase from Chaetomium thermophilum, a Promising Enzymatic Solution for Biotechnical CO2 Fixation.

Çakar MM, Ruupunen J, Mangas-Sanchez J, Birmingham WR, et alBiotech Lett 2020, 42, 2251-2262

Characterization and mutagenesis of imine reductases for the investigation of structure activity relationships.

Montgomery SL, Pushpanath A, Heath RS, Marshall JR, Klemstein U, Galman JL, Woodlock D, Bisagni S,Taylor CL, Mangas-Sanchez J, et al. Science Advances 2020, 6, eaay9320.

One-Pot Biocatalytic Cascade Reduction of Cyclic Enimines for the Preparation of Diastereomerically Enriched N-Heterocycles.

Thorpe TW, France SP, Hussain S, Marshall JR, Zawodny W, Mangas-Sanchez J, et al. J Am Chem Soc. 2019,141, 19208–19213

Enantioselective Synthesis of Chiral Vicinal Amino Alcohols Using Amine Dehydrogenases

Chen FF, Cosgrove SC, Birmingham WR, Mangas-Sanchez J., Citoler J, Thompson MP, et al. ACS Catal. 2019, 9, 11813–11818.

Biocatalytic N-alkylation of amines using either primary alcohols or carboxylic acids via reductive aminase cascades.

Ramsden JI, Heath RS, Derrington SR, Montgomery SL, Mangas-Sanchez J. et. al. J. Am. Chem. Soc. 2019, 141, 1201-1206.

A generic platform for the immobilisation of engineered biocatalysts

Matthew P. Thompson, Sasha R. Derrington, Rachel S. Heath, Joanne L. Porter, Juan Mangas-Sanchez, Paul N. Devine, Matthew D. Truppo and Nicholas J. Turner. Tetrahedron 2019, 75, 327-334

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